The Dynamic interplay between bleeding phenotype and baseline factor level in moderate and mild hemophilia A and B (the DYNAMO study), Netherlands

Registration Status: Completed

Objective: The DYNAMO biobank contains left-over material collected in the context of the DYNAMO study. The DYNAMO study is an international multicenter study investigating the association between FVIII and FIX plasma levels and the bleeding phenotype. Data is collected on demographics, physical activity levels, musculoskeletal status, genotype, measured factor levels (both one-stage and chromogenic), the nature and duration of all bleeding episodes, type of treatment and treatment response. Central laboratory measurements will be performed for FVIII or FIX levels.

Registered Biobank Name	The Dynamic interplay between bleeding phenotype and baseline factor level in moderate and mild hemophilia A and B (the DYNAMO study)
Biobank Leader	Dr. C.J. Fijnvandraat
Country	Netherlands
Email for biobank inquiries	c.j.fijvandraat@amc.nl
Principal Investigator	Dr. Shannon Jackson (Vancouver site), Dr. C.J. Fijnvandraat (leading site at Amsterdam)
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).