The Use of Patient-Derived Tumor Tissue as a Preclinical Tool to Facilitate Identification, Validation and Monitoring of Factors Driving Cancer Development and Progression, Canada

Registration Status: Completed

Objective: Patient tumor samples obtained following standard of care surgical resection will be obtained and clinically annotated. Samples will be used to generate cell lines, organoids, patient-derived explants, or patient-derived xenograft models which will be used for testing of novel anti-cancer or cancer detection agents. Portions of samples will be snap frozen for future use to isolate RNA or protein for subsequent analysis, in addition to fixing a portion in formalin for validation of potential targets of interest by IHC methods.

Registered Biobank Name	The Use of Patient-Derived Tumor Tissue as a Preclinical Tool to Facilitate Identification, Validation and Monitoring of Factors Driving Cancer Development and Progression
Biobank Leader	Christina Addison
Country	Canada
Email for biobank inquiries	caddison@ohri.ca
Principal Investigator	Christina Addison; Adam Shuhendler
Website
User Type Mono: A biobank that supports a specific research project, may have few staff members, a small-scale accrual scope with little to no initial intention of releasing or distributing biospecimens to secondary parties Oligo: A biobank that supports several research groups or clinical trials, may or may not be designed to release biospecimens outside their collaborative group Poly: A biobank that has generally a larger accrual scope, resources, and multiple users outside the biobank proper

Biospecimen Collected:

Cohort Highlights

100 cases Next Generation Sequencing assay to detect all classes of genetic variant in Lung Cancer using a single Diagnostic test.
200 cases Colorectal TMA for QC purposes in support of study of tumor infiltrating lymphocytes in ovarian cancer tissues.
Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). Start with Triple negatives.
125 cases Breast tumour and metastatic lymph nodes in breast cancer cases with outcomes of metastasis to lung or bone.
100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. FFPE, frozen, BC.
200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested).